SAMUEL K. COHN, JR. RESPONDS

The chloroform still of Dr. Samuel Guthrie, Jr.

, Unkeless , and Cohn 185

Mononuclear leukocytes are able to destroy tumor cells under a variety of circumstances. In few such instances is the biochemical basis of cytotoxicity understood. Recently, we demonstra ted that activated macrophages, s t imulated by phorbol myristate acetate (PMA), 1 secreted substantial amounts o f hydrogen peroxide (1). The release o f this oxidant from macrophages correlated with the extra...

Samuel Dales

Subsequent to the demons t ra t ion tha t the major h i s tocompa t ib i l i t y molecu la r complex (MHC) 1 is a necessary de t e rminan t in i m m u n e specific ki l l ing by cytotoxic lymphocytes (CTL) in virus-infected target cells (1), e luc ida t ion of the p h e n o m e n o n of M H C restr ict ion has been sought th rough several different exper imen ta l approaches. O n the basis of d...

Henry Cohn and Abhinav Kumar

We use techniques of Bannai and Sloane to give a new proof that there is a unique (22, 891, 1/4) spherical code; this result is implicit in a recent paper by Cuypers. We also correct a minor error in the uniqueness proof given by Bannai and Sloane for the (23, 4600, 1/3) spherical code.

Zanvil Alexander Cohn 1926-1993

Zanvil Alexander Cohn, an editor of this Journal since 1973, died suddenly on June 28, 1993. Cohn is best known as the father of the current era of macrophage biology. Many of his scientific accomplishments are recounted here, beginning with seminal studies on the granules of phagocytes that were performed with his close colleague and former editor of this Journal, James Hirsch. Cohn and Hirsch...